Visualizing synaptic vesicle turnover and pool refilling driven by calcium nanodomains at presynaptic active zones of ribbon synapses.

ABSTRACT: Ribbon synapses of photoreceptor cells and second-order bipolar neurons in the retina are specialized to transmit graded signals that encode light intensity. Neurotransmitter release at ribbon synapses exhibits two kinetically distinct components, which serve different sensory functions. The faster component is depleted within milliseconds and generates transient postsynaptic responses that emphasize changes in light intensity. Despite the importance of this fast release for processing temporal and spatial contrast in visual signals, the physiological basis for this component is not precisely known. By imaging synaptic vesicle turnover and Ca(2+) signals at single ribbons in zebrafish bipolar neurons, we determined the locus of fast release, the speed and site of Ca(2+) influx driving rapi

SUBMITTER: Vaithianathan T 

PROVIDER: S-EPMC4060678 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature