Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.

ABSTRACT: The rate of protein evolution is determined by a combination of selective pressure on protein function and biophysical constraints on protein folding and structure. Determining the relative contributions of these properties is an unsolved problem in molecular evolution with broad implications for protein engineering and function prediction. As a case study, we examined the structural divergence of the rapidly evolving o-succinylbenzoate synthase (OSBS) family, which catalyzes a step in menaquinone synthesis in diverse microorganisms and plants. On average, the OSBS family is much more divergent than other protein families from the same set of species, with the most divergent family members sharing <15% sequence identity. Comparing 11 representative structures revealed that loss of quaterna

SUBMITTER: Odokonyero D 

PROVIDER: S-EPMC4060685 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature