Evaluation of cytotoxicity and DNA damage response with analysis of intracellular ATM signaling pathways.

ABSTRACT: Maintenance of genome integrity by preventing and overcoming DNA damage is critical for cell survival. Deficiency or aberrancy in the DNA damage response, for example, through ataxia telangiectasia mutated (ATM) signaling, lead to pathophysiological perturbations in organs throughout the body. Therefore, control of DNA damage is of major interest for development of therapeutic agents. Such efforts will greatly benefit from convenient and simple diagnostic and/or drug development tools to demonstrate whether ATM and related genes have been activated and to then determine whether these have been returned to normal levels of activity because pathway members sense and also repair DNA damage. To overcome difficulties in analyzing differences in multitudinous ATM pathway members following DNA da

SUBMITTER: Bandi S 

PROVIDER: S-EPMC4060777 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature