Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane.

ABSTRACT:

Background

Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates of glucose fermentation in the presence of normal oxygen concentrations, also known as the Warburg effect. This metabolism is considered abnormal because it violates the standard model of cellular energy production that assumes glucose metabolism is predominantly governed by oxygen concentrations and, therefore, fermentative glycolysis is an emergency back-up for periods of hypoxia. Though several hypotheses have been proposed for the origin of aerobic glycolysis, its biological basis in cancer and normal cells is still not well understood.

Results

We examined changes in glucose metabolism following perturbations in membrane activity in different normal and tumor cell lines and fou

SUBMITTER: Epstein T 

PROVIDER: S-EPMC4060846 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature