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Chemogenesis of an antiangiogenic glycosaminoglycan.

ABSTRACT: In this letter we report a facile chemical conversion of heparin, a potent anticoagulant with minimal antiangiogenic activity, into an effective antiangiogenic glycosaminoglycan through optimized chemical approaches. This work highlights the potential for industrial scale production of a therapeutic anticancer glycosaminoglycan.

SUBMITTER: Raman K 

PROVIDER: S-EPMC4060934 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Chemogenesis of an antiangiogenic glycosaminoglycan.

Raman Karthik K   Arungundram Sailaja S   Kuberan Balagurunathan B  

ACS medicinal chemistry letters 20140404 6

In this letter we report a facile chemical conversion of heparin, a potent anticoagulant with minimal antiangiogenic activity, into an effective antiangiogenic glycosaminoglycan through optimized chemical approaches. This work highlights the potential for industrial scale production of a therapeutic anticancer glycosaminoglycan. ...[more]

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