High resolution MRI anatomy of the cat brain at 3 Tesla.

ABSTRACT:

Background

Feline models of neurologic diseases, such as lysosomal storage diseases, leukodystrophies, Parkinson's disease, stroke and NeuroAIDS, accurately recreate many aspects of human disease allowing for comparative study of neuropathology and the testing of novel therapeutics. Here we describe in vivo visualization of fine structures within the feline brain that were previously only visible post mortem.

New method

3Tesla MR images were acquired using T1-weighted (T1w) 3D magnetization-prepared rapid gradient echo (MPRAGE) sequence (0.4mm isotropic resolution) and T2-weighted (T2w) turbo spin echo (TSE) images (0.3mm×0.3mm×1mm resolution). Anatomic structures were identified based on feline and canine histology.

Results

T2w high resolution MR images with detailed

SUBMITTER: Gray-Edwards HL 

PROVIDER: S-EPMC4060963 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature