Fed state prior to hemorrhagic shock and polytrauma in a porcine model results in altered liver transcriptomic response.

ABSTRACT: Hemorrhagic shock is a leading cause of trauma-related mortality in both civilian and military settings. Resuscitation often results in reperfusion injury and survivors are susceptible to developing multiple organ failure (MOF). The impact of fed state on the overall response to shock and resuscitation has been explored in some murine models but few clinically relevant large animal models. We have previously used metabolomics to establish that the fed state results in a different metabolic response in the porcine liver following hemorrhagic shock and resuscitation. In this study, we used our clinically relevant model of hemorrhagic shock and polytrauma and the Illumina HiSeq platform to determine if the liver transcriptomic response is also altered with respect to fed state. Functional ana

SUBMITTER: Determan C 

PROVIDER: S-EPMC4061062 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature