Identification of genomic features in environmentally induced epigenetic transgenerational inherited sperm epimutations.

ABSTRACT: A variety of environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. The process involves exposure of a gestating female and the developing fetus to environmental factors that promote permanent alterations in the epigenetic programming of the germline. The molecular aspects of the phenomenon involve epigenetic modifications (epimutations) in the germline (e.g. sperm) that are transmitted to subsequent generations. The current study integrates previously described experimental epigenomic transgenerational data and web-based bioinformatic analyses to identify genomic features associated with these transgenerationally transmitted epimutations. A previously identified genomic feature associated with these epimutations

SUBMITTER: Guerrero-Bosagna C 

PROVIDER: S-EPMC4061094 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature