On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation.

ABSTRACT:

Background

Protein sequence similarities to any types of non-globular segments (coiled coils, low complexity regions, transmembrane regions, long loops, etc. where either positional sequence conservation is the result of a very simple, physically induced pattern or rather integral sequence properties are critical) are pertinent sources for mistaken homologies. Regretfully, these considerations regularly escape attention in large-scale annotation studies since, often, there is no substitute to manual handling of these cases. Quantitative criteria are required to suppress events of function annotation transfer as a result of false homology assignments.

Results

The sequence homology concept is based on the similarity comparison between the structural elements, the basic buildin

SUBMITTER: Wong WC 

PROVIDER: S-EPMC4061105 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature