The potential impact of HPV-16 reactivation on prevalence in older Australians.

ABSTRACT:

Background

Some regional cross-sectional human papillomavirus (HPV) DNA prevalence data show an increase in prevalence in older women, the reasons for which are as yet unknown. A recently published study suggests that the increase may be at least partly due to reactivation of latent HPV in menopausal women.

Methods

We developed a dynamic mathematical model of HPV-16 transmission to estimate the key consequences of hypothetical HPV-16 reactivation in the Australian heterosexual population. We only consider a worst case scenario with regard to reactivation in the Australian setting when all women who are latently infected reactivate and, wherever feasible, we choose model parameter values which may lead to a more pronounced reactivation. The ongoing National HPV vaccination pr

SUBMITTER: Korostil IA 

PROVIDER: S-EPMC4061121 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature