Analysis of differentially expressed genes in cold-exposed mice to investigate the potential causes of cold-induced hypertension.

ABSTRACT: Cold exposure is considered to be an important contributing factor to the high morbidity of hypertension. In order to elucidate the cause and mechanism of cold-induced hypertension (CIH), gene expression analysis was performed on microarray data for two groups of cold-exposed mice (4°C for 1 week and 4°C for 5 weeks, three replicates per group) and their respective control groups maintained at 30°C. Analysis results indicated that the differentially expressed genes with the most significance were associated with adaptive thermogenesis, fatty acid metabolism and energy metabolism. The expected marked increase in metabolism during cold exposure caused tissue hypoxia. Genes involved in the hypoxia-inducible factor signaling pathway were activated. In addition, genes associated with oxidative

SUBMITTER: Tuo B 

PROVIDER: S-EPMC4061198 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature