Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States.

ABSTRACT:

Objective

To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences.

Design

Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US.

Setting

General population.

Participants

26,018 men and women aged 50-79 years.

Main outcome measures

All-cause, cardiovascular, and cancer mortality.

Results

25(OH)D concentrations varied strongly by season (higher in summer), country (higher in US and northern Europe) and sex (higher in men), but no consistent trend with age was observed. During follow-up, 6695 study participants died, among whom 2624

SUBMITTER: Schottker B 

PROVIDER: S-EPMC4061380 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature