Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.

ABSTRACT:

Background

Prion diseases are fatal neurodegenerative disorders whose pathogenesis mechanisms are not fully understood. In this context, the analysis of gene expression alterations occurring in prion-infected animals represents a powerful tool that may contribute to unravel the molecular basis of prion diseases and therefore discover novel potential targets for diagnosis and therapeutics. Here we present the first large-scale transcriptional profiling of brains from BSE-infected cynomolgus macaques, which are an excellent model for human prion disorders.

Results

The study was conducted using the GeneChip® Rhesus Macaque Genome Array and revealed 300 transcripts with expression changes greater than twofold. Among these, the bioinformatics analysis identified 86 genes with kno

SUBMITTER: Barbisin M 

PROVIDER: S-EPMC4061447 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature