Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors.

ABSTRACT: We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.

SUBMITTER: Myung N 

PROVIDER: S-EPMC4061458 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature