Tigecycline use in critically ill patients: a multicentre prospective observational study in the intensive care setting.

ABSTRACT:

Purpose

This prospective observational study aimed at describing prescription patterns of tigecycline and patient outcomes in 26 French intensive care units (ICU).

Methods

Data of consecutive cases of adult patients treated with tigecycline were collected from the initiation until 7 days after the end of treatment. Response to treatment was classified as success, failure or undetermined and analyses were presented according to severity (SOFA score <7 or ≥7). Survival was recorded at 28 days.

Results

A total of 156 patients were included (64% male, age 60 ± 15 years). At inclusion, 53% had a SOFA score ≥7; 93% had received prior anti-infective agents. Tigecycline was given as first-line treatment in 47% of patients, mostly in combination (67%), for intra-abdominal (IAI

SUBMITTER: Montravers P 

PROVIDER: S-EPMC4061476 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature