Comparison of 4D-microSPECT and microCT for murine cardiac function.

ABSTRACT:

Purpose

The objective of this study was to compare a new generation of four-dimensional micro-single photon emission computed tomography (microSPECT) with microCT for the quantitative in vivo assessment of murine cardiac function.

Procedures

Four-dimensional isotropic cardiac images were acquired from anesthetized normal C57BL/6 mice with either microSPECT (n = 6) or microCT (n = 6). One additional mouse with myocardial infarction (MI) was scanned with both modalities. Prior to imaging, mice were injected with either technetium tetrofosmin for microSPECT or a liposomal blood pool contrast agent for microCT. Segmentation of the left ventricle (LV) was performed using Vitrea (Vital Images) software, to derive global and regional function.

Results

Measures of global LV f

SUBMITTER: Befera NT 

PROVIDER: S-EPMC4061569 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature