Midkine expression in high grade gliomas: Correlation of this novel marker with proliferation and survival in human gliomas.

ABSTRACT:

Background

High-grade primary glioma have poor prognosis and predictive biomarkers is very important. Midkine (MDK), a heparin-binding growth factor, is important in regulating carcinogenesis, cell proliferation, mitogenesis, and angiogenesis. This study aimed to identify over-expression of MDK in gliomas and correlate this with clinical outcomes. The authors put forward their hypothesis correlating proliferation and poor survival with over-expression of this novel protein.

Methods

Two datasets from Gene Expression Omnibus (GEO) included human data of 100 and 180 patients, respectively. The MDK expression, World Health Organization (WHO) pathological grade, sex, age, and survival time were identified for statistical analysis.

Results

A search of the GEO profile reveal

SUBMITTER: Cheng YP 

PROVIDER: S-EPMC4061577 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature