Bobby Sox homology regulates odontoblast differentiation of human dental pulp stem cells/progenitors.

ABSTRACT:

Background

Transcription factors have been implicated in regulating the differentiation of odontoblasts from dental pulp stem cells/progenitors (DPSCs/progenitors), but their regulatory network is not completely understood.

Result

New transcription factors that control the odontoblast differentiation of human DPSCs/progenitors were analyzed using a microarray. The result revealed bobby sox homolog (BBX) to be expressed most strongly during odontoblast differentiation. Validation using RT-PCR also revealed the strong expression of BBX during the odontoblast differentiation of DPSCs/progenitors. BBX expression was also detected in adult molar odontoblasts and other tissues, including the heart, kidney, testis, and bone marrow. To understand the role of BBX in odontoblast diffe

SUBMITTER: Choi YA 

PROVIDER: S-EPMC4062286 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature