Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes.

ABSTRACT:

Background

The anti-diabetic agent acarbose reduces postprandial glucose excursions. We have evaluated the effect of randomized treatment with acarbose on the progression of carotid intima-media thickness (IMT) in early diabetes.

Methods

The Early Diabetes Intervention Program was a randomized trial of acarbose versus placebo in 219 participants with early diabetes characterized by glucose values over 11.1 mmol/L 2 h after a 75 g oral glucose load and a mean HbA1c of 6.3%. IMT was measured at baseline and yearly. Follow-up was discontinued if participants progressed to the study glucose endpoints; IMT readings were available for a median of 2 years, with 72 subjects followed for 5 years.

Results

Progressive increases in IMT were seen in both treatment groups, but prog

SUBMITTER: Patel YR 

PROVIDER: S-EPMC4062388 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature