Serum and tissue zinc in epithelial malignancies: a meta-analysis.

ABSTRACT:

Background and objectives

Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper.

Methods

Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis.

Results

Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size = -1.04), head and neck (effect size = -1.43), breast (effect size = -0.9

SUBMITTER: Gumulec J 

PROVIDER: S-EPMC4062461 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature