Failure of miltefosine treatment for visceral leishmaniasis in children and men in South-East Asia.

ABSTRACT:

Background

High frequency of relapse in miltefosine-treated visceral leishmaniasis (VL) patients in India and Nepal followed up for twelve months.

Objective

To identify epidemiological and clinical risk factors for relapse of VL in patients recently treated with standard dosing of miltefosine in India and Nepal.

Design

Prospective observational study in three Primary Health Centers and one reference center in Muzaffarpur district, Bihar, India; and two zonal hospitals and a university hospital in South-east Nepal; records of all consenting patients diagnosed with VL and treated with miltefosine according to the current treatment guidelines of the Kala azar elimination program between 2009 and 2011.

Results

We compared the clinical records of 78 cases of relapse

SUBMITTER: Ostyn B 

PROVIDER: S-EPMC4062493 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature