Is CD133 expression a prognostic biomarker of non-small-cell lung cancer? A systematic review and meta-analysis.

ABSTRACT:

Background

The clinical and prognostic significance of CD133 in non-small-cell lung cancer (NSCLC) remains controversial. To clarify a precise determinant of the clinical significance of CD133, we conducted a systematic review and meta-analysis to evaluate the association of CD133 with prognosis and clinicopathological features of NSCLC patients.

Methods

The electronic and manual searches were performed through the database of Pubmed, Medline, Web of Science, Scopus, and Chinese CNKI (from January 1, 1982 to January 1, 2014) for titles and abstracts by using the following keywords: "CD133", "ac133" or "Prominin-1", and "lung cancer" to identify the studies eligible for our analysis. Meta-analysis was performed by using Review Manager 5.0 and the outcomes included the overall

SUBMITTER: Wu H 

PROVIDER: S-EPMC4062503 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature