An eight-miRNA signature as a potential biomarker for predicting survival in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma is a heterogernous disease that creates challenges for classification and management. The purpose of this study is to identify specific miRNA markers closely associated with the survival of LUAD patients from a large dataset of significantly altered miRNAs, and to assess the prognostic value of this miRNA expression profile for OS in patients with LUAD.

Methods

We obtained miRNA expression profiles and corresponding clinical information for 372 LUAD patients from The Cancer Genome Atlas (TCGA), and identified the most significantly altered miRNAs between tumor and normal samples. Using survival analysis and supervised principal components method, we identified an eight-miRNA signature for the prediction of overall survival (OS) of LUAD patients

SUBMITTER: Li X 

PROVIDER: S-EPMC4062505 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature