A carbonate-forming Baeyer-Villiger monooxygenase.

ABSTRACT: Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC4062580 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature