Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

ABSTRACT:

Purpose

Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeutic targets and perform comparative analyses of lung SCC, we probed somatic genome alterations of lung SCC by using samples from Korean patients.

Patients and methods

We performed whole-exome sequencing of DNA from 104 lung SCC samples from Korean patients and matched normal DNA. In addition, copy-number analysis and transcriptome analysis were conducted for a subset of these samples. Clinical association with cancer-specific somatic alterations was investigated.

Results

This cance

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4062710 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature