Identification of endoglin-dependent BMP-2-induced genes in the murine periodontal ligament cell line PDL-L2.

ABSTRACT:

Background

The periodontal ligament (PDL), connective tissue located between the cementum of teeth and alveolar bone of the mandibula, plays an important role in the maintenance and regeneration of periodontal tissues. We reported previously that endoglin was involved in the BMP-2-induced osteogenic differentiation of mouse PDL cells, which is associated with Smad-2 phosphorylation but not Smad-1/5/8 phosphorylation. In this study, to elucidate the detailed mechanism underlying the BMP-2 signalling pathway unique to PDL cells, we performed a microarray analysis to identify BMP-2-inducible genes in PDL-L2 cells, a mouse PDL-derived cell line, with or without endoglin knockdown.

Findings

Sixty-four genes were upregulated more than twofold by BMP-2 in PDL-L2 cells. Of these gen

SUBMITTER: Ishibashi O 

PROVIDER: S-EPMC4062770 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature