Chromosome territories reposition during DNA damage-repair response.

ABSTRACT:

Background

Local higher-order chromatin structure, dynamics and composition of the DNA are known to determine double-strand break frequencies and the efficiency of repair. However, how DNA damage response affects the spatial organization of chromosome territories is still unexplored.

Results

Our report investigates the effect of DNA damage on the spatial organization of chromosome territories within interphase nuclei of human cells. We show that DNA damage induces a large-scale spatial repositioning of chromosome territories that are relatively gene dense. This response is dose dependent, and involves territories moving from the nuclear interior to the periphery and vice versa. Furthermore, we have found that chromosome territory repositioning is contingent upon double-stran

SUBMITTER: Mehta IS 

PROVIDER: S-EPMC4062845 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature