Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy.

ABSTRACT:

Background

Androgen-deprivation therapy (ADT) is standard treatment for locally advanced or metastatic prostate cancer (PCa). Many patients develop castration resistance (castration-resistant PCa [CRPC]) after approximately 2-3 yr, with a poor prognosis. The molecular mechanisms underlying CRPC progression are unclear.

Objective

To undertake quantitative tumour transcriptome profiling prior to and following ADT to identify functionally important androgen-regulated pathways or genes that may be reactivated in CRPC.

Design, setting, and participants

RNA sequencing (RNA-seq) was performed on tumour-rich, targeted prostatic biopsies from seven patients with locally advanced or metastatic PCa before and approximately 22 wk after ADT initiation. Differentially regulated gen

SUBMITTER: Rajan P 

PROVIDER: S-EPMC4062940 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature