Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages.

ABSTRACT: In gastrointestinal stromal tumor (GIST), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

SUBMITTER: Cavnar MJ 

PROVIDER: S-EPMC4063150 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature