The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer.

ABSTRACT:

Background

FOXO4, a member of the FOXO family of transcription factors, is currently the focus of intense study. Its role and function in gastric cancer have not been fully elucidated. The present study was aimed to investigate the expression profile of FOXO4 in gastric cancer and the effect of FOXO4 on cancer cell growth and metastasis.

Methods

Immunohistochemistry, Western blotting and qRT-PCR were performed to detect the FOXO4 expression in gastric cancer cells and tissues. Cell biological assays, subcutaneous tumorigenicity and tail vein metastatic assay in combination with lentivirus construction were performed to detect the impact of FOXO4 to gastric cancer in proliferation and metastasis in vitro and in vivo. Confocal and qRT-PCR were performed to explore the mechanis

SUBMITTER: Su L 

PROVIDER: S-EPMC4063225 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature