PVT: an efficient computational procedure to speed up next-generation sequence analysis.

ABSTRACT:

Background

High-throughput Next-Generation Sequencing (NGS) techniques are advancing genomics and molecular biology research. This technology generates substantially large data which puts up a major challenge to the scientists for an efficient, cost and time effective solution to analyse such data. Further, for the different types of NGS data, there are certain common challenging steps involved in analysing those data. Spliced alignment is one such fundamental step in NGS data analysis which is extremely computational intensive as well as time consuming. There exists serious problem even with the most widely used spliced alignment tools. TopHat is one such widely used spliced alignment tools which although supports multithreading, does not efficiently utilize computational resource

SUBMITTER: Maji RK 

PROVIDER: S-EPMC4063226 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature