Pharmacogenetics of antihypertensive treatment: detailing disciplinary dissonance.

ABSTRACT: Hypertension is a common condition associated with increased cardiovascular morbidity and mortality. In the USA only approximately a third of those who are aware of their hypertensive status successfully control their blood pressure. One reason for this is the unpredictable response individuals have to treatment. Clinicians must often rely on empirical methods to match patients with effective drug treatment. Hypertension pharmacogenetics seeks to find genetic predictors of response to drugs that lower blood pressure and to translate this knowledge into clinical practice. To date, around 60 studies have investigated associations between genetic polymorphisms and response to antihypertensive drugs. Here we review 18 studies that have been published since 2005. While consonant findings that a

SUBMITTER: Arnett DK 

PROVIDER: S-EPMC4063280 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature