PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst.

ABSTRACT: At the end of the preimplantation period, the inner cell mass (ICM) of the mouse blastocyst is composed of two distinct cell lineages, the pluripotent epiblast (EPI) and the primitive endoderm (PrE). The current model for their formation involves initial co-expression of lineage-specific markers followed by mutual-exclusive expression resulting in a salt-and-pepper distribution of lineage precursors within the ICM. Subsequent to lineage commitment, cell rearrangements and selective apoptosis are thought to be key processes driving and refining the emergence of two spatially distinct compartments. Here, we have addressed a role for Platelet Derived Growth Factor (PDGF) signaling in the regulation of programmed cell death during early mouse embryonic development. By combining genetic and pha

SUBMITTER: Artus J 

PROVIDER: S-EPMC4063320 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature