Mitochondrial DNA deletions and depletion within paraspinal muscles.

ABSTRACT:

Aims

Although mitochondrial abnormalities have been reported within paraspinal muscles in patients with axial weakness and neuromuscular disease as well as with ageing, the basis of respiratory deficiency in paraspinal muscles is not known. This study aimed to determine the extent and basis of respiratory deficiency in paraspinal muscles from cases undergoing surgery for degenerative spinal disease and post mortem cases without a history of spinal disease, where age-related histopathological changes were previously reported.

Methods

Cervical and lumbar paraspinal muscles were obtained peri-operatively from 13 patients and from six post mortem control cases (age range 18-82 years) without a neurological disease. Sequential COX/SDH (mitochondrial respiratory chain complex IV/c

SUBMITTER: Campbell GR 

PROVIDER: S-EPMC4063338 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature