Ontology highlight
ABSTRACT:
SUBMITTER: Grabocka E
PROVIDER: S-EPMC4063560 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Cancer cell 20140201 2
Mutations in KRAS are prevalent in human cancers and universally predictive of resistance to anticancer therapeutics. Although it is widely accepted that acquisition of an activating mutation endows RAS genes with functional autonomy, recent studies suggest that the wild-type forms of Ras may contribute to mutant Ras-driven tumorigenesis. Here, we show that downregulation of wild-type H-Ras or N-Ras in mutant K-Ras cancer cells leads to hyperactivation of the Erk/p90RSK and PI3K/Akt pathways and ...[more]