Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation.

ABSTRACT: For a rapid induction and efficient resolution of the inflammatory response, gene expression in cells of the immune system is tightly regulated at the transcriptional and post-transcriptional level. The control of mRNA translation has emerged as an important determinant of protein levels, yet its role in macrophage activation is not well understood. We systematically analyzed the contribution of translational regulation to the early phase of the macrophage response by polysome fractionation from mouse macrophages stimulated with lipopolysaccharide (LPS). Individual mRNAs whose translation is specifically regulated during macrophage activation were identified by microarray analysis. Stimulation with LPS for 1 h caused translational activation of many feedback inhibitors of the inflammatory

SUBMITTER: Schott J 

PROVIDER: S-EPMC4063670 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature