Identifying crucial parameter correlations maintaining bursting activity.

ABSTRACT: Recent experimental and computational studies suggest that linearly correlated sets of parameters (intrinsic and synaptic properties of neurons) allow central pattern-generating networks to produce and maintain their rhythmic activity regardless of changing internal and external conditions. To determine the role of correlated conductances in the robust maintenance of functional bursting activity, we used our existing database of half-center oscillator (HCO) model instances of the leech heartbeat CPG. From the database, we identified functional activity groups of burster (isolated neuron) and half-center oscillator model instances and realistic subgroups of each that showed burst characteristics (principally period and spike frequency) similar to the animal. To find linear correlations amon

SUBMITTER: Doloc-Mihu A 

PROVIDER: S-EPMC4063674 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature