An expanded Notch-Delta model exhibiting long-range patterning and incorporating MicroRNA regulation.

ABSTRACT: Notch-Delta signaling is a fundamental cell-cell communication mechanism that governs the differentiation of many cell types. Most existing mathematical models of Notch-Delta signaling are based on a feedback loop between Notch and Delta leading to lateral inhibition of neighboring cells. These models result in a checkerboard spatial pattern whereby adjacent cells express opposing levels of Notch and Delta, leading to alternate cell fates. However, a growing body of biological evidence suggests that Notch-Delta signaling produces other patterns that are not checkerboard, and therefore a new model is needed. Here, we present an expanded Notch-Delta model that builds upon previous models, adding a local Notch activity gradient, which affects long-range patterning, and the activity of a regul

SUBMITTER: Chen JS 

PROVIDER: S-EPMC4063677 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature