The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis.

ABSTRACT:

Background

Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as infertility, pelvic pain, menstrual cycle abnormalities and increased risk of certain cancers. However, many of the current clinical treatments for endometriosis are not sufficiently effective and yield unacceptable side effects. There is clearly an urgent need to identify new molecular mechanisms that critically underpin the initiation and progression of endometriosis in order to develop more specific and effective therapeutics which lack the side effects of current therapies. The aim of this review is to discuss how nuclear receptors (NRs) and th

SUBMITTER: Han SJ 

PROVIDER: S-EPMC4063700 | biostudies-literature | 2014 Jul-Aug

REPOSITORIES: biostudies-literature