High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation.

ABSTRACT: Currently very little is known about the differential expression and function of the transcription factor SOX5 during B cell maturation. We identified two new splice variants of SOX5 in human B cells, encoding the known L-SOX5B isoform and a new shorter isoform L-SOX5F. The SOX5 transcripts are highly expressed during late stages of B-cell differentiation, including atypical memory B cells, activated CD21low B cells and germinal center B cells of tonsils. In tonsillar sections SOX5 expression was predominantly polarized to centrocytes within the light zone. After in vitro stimulation, SOX5 expression was down-regulated during proliferation while high expression levels were permissible for plasmablast differentiation. Overexpression of L-SOX5F in human primary B lymphocytes resulted in redu

SUBMITTER: Rakhmanov M 

PROVIDER: S-EPMC4063782 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature