Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

To investigate the association between genetic polymorphisms of growth factor-related genes and prognosis in patients with advanced esophageal squamous cell carcinoma (ESCC).

Patients and methods

A total of 334 ESCC patients with advanced tumor stages (stages IIB, III and IV) were enrolled in the study. The genotypes of 14 candidate single nucleotide polymorphisms (SNPs) involved in growth factor-related functions were analyzed using iPLEX Gold technology from the genomic DNA of peripheral leukocytes, and were correlated with the clinical outcome of patients. Serum levels of growth factors were examined by enzyme-linked immunosorbent assay (ELISA).

Results

The genetic polymorphisms of EGF:rs4444903, EGF:rs2237051 and VEGF:rs2010963 showed significant associati

SUBMITTER: Yang PW 

PROVIDER: S-EPMC4063891 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature