Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster.

ABSTRACT: Systems biology is an approach to dissection of complex traits that explicitly recognizes the impact of genetic, physiological, and environmental interactions in the generation of phenotypic variation. We describe comprehensive transcriptional and metabolic profiling in Drosophila melanogaster across four diets, finding little overlap in modular architecture. Genotype and genotype-by-diet interactions are a major component of transcriptional variation (24 and 5.3% of the total variation, respectively) while there were no main effects of diet (<1%). Genotype was also a major contributor to metabolomic variation (16%), but in contrast to the transcriptome, diet had a large effect (9%) and the interaction effect was minor (2%) for the metabolome. Yet specific principal components of these mol

SUBMITTER: Reed LK 

PROVIDER: S-EPMC4063932 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature