A prognostic model of triple-negative breast cancer based on miR-27b-3p and node status.

ABSTRACT:

Objective

Triple-negative breast cancer (TNBC) is an aggressive but heterogeneous subtype of breast cancer. This study aimed to identify and validate a prognostic signature for TNBC patients to improve prognostic capability and to guide individualized treatment.

Methods

We retrospectively analyzed the prognostic performance of clinicopathological characteristics and miRNAs in a training set of 58 patients with invasive ductal TNBC diagnosed between 2002 and 2012. A prediction model was developed based on independent clinicopathological and miRNA covariates. The prognostic value of the model was further validated in a separate set of 41 TNBC patients diagnosed between 2007 and 2008.

Results

Only lymph node status was marginally significantly associated with poor progno

SUBMITTER: Shen S 

PROVIDER: S-EPMC4063964 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature