Acute hepatitis C in HIV-1 infected Japanese Cohort: single center retrospective cohort study.

ABSTRACT:

Objectives

HCV co-infection is a poor prognostic factor in HIV-1-infected patients. Although the number of newly reported patients who show seroconversion is increasing, the clinical features are still unclear, especially in Asian countries.

Design

A single-center retrospective cohort study of patients diagnosed between 2001-2012.

Methods

Acute hepatitis C (AHC) was diagnosed upon detection of high serum ALT (>100 IU) followed by anti-HCV seroconversion. Clinical characteristics, HIV-1-related immunological status and IL-28B genotypes (rs12979860, rs8099917) were collected. We compared these variables between patients with and without spontaneous clearance of HCV and between responders and non-responders to treatment with pegylated interferon (PEG-IFN) plus ribavirin.

SUBMITTER: Ishikane M 

PROVIDER: S-EPMC4063971 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature