Image-guided pro-angiogenic therapy in diabetic stroke mouse models using a multi-modal nanoprobe.

ABSTRACT:

Purpose

The efficacy of pro-angiogenic therapy is difficult to evaluate with current diagnostic modalities. The objectives were to develop a non-invasive imaging strategy to define the temporal characteristics of angiogenesis and to evaluate the response to pro-angiogenic therapy in diabetic stroke mouse models.

Methods

A home-made ανβ3 integrin-targeted multi-modal nanoprobe was intravenously injected into mouse models at set time points after photothrombotic stroke. Magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) imaging were carried out at 24 h post-injection. Bone marrow-derived endothelial progenitor cells (EPCs) were infused into the mouse models of ischemic stroke to stimulate angiogenesis.

Results

The peak signal intensity in the ischemi

SUBMITTER: Bai YY 

PROVIDER: S-EPMC4063977 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature