Risk of hepatobiliary cancer after solid organ transplant in the United States.

ABSTRACT:

Background & aims

Studies of liver cancer risk in recipients of solid organ transplants generally have been small, yielding mixed results, and little is known about biliary tract cancers among transplant recipients.

Methods

We identified incident hepatobiliary cancers among 201,549 US recipients of solid organs, from 1987 through 2008, by linking data from the US transplant registry with 15 cancer registries. We calculated standardized incidence ratios (SIRs), comparing risk relative to the general population. We also calculated incidence rate ratios (RRs), comparing risk for hepatocellular carcinoma (HCC) and total (intrahepatic and extrahepatic) cholangiocarcinoma among subgroups of recipients.

Results

Of transplant recipients, 165 developed hepatobiliary cancers (S

SUBMITTER: Koshiol J 

PROVIDER: S-EPMC4064001 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature