Association of MYO9B gene polymorphisms with inflammatory bowel disease in Chinese Han population.

ABSTRACT:

Aim

To explore the association of MYO9B gene polymorphisms with clinical phenotypes and intestinal permeability of individuals with inflammatory bowel disease (IBD) in China.

Methods

A total of 442 IBD patients and 402 healthy volunteers were genotyped for two single nucleotides (rs962917 and rs1545620) using the ligase detection reaction and polymerase chain reaction. Allelic and genotype frequency analyses were performed for the two groups. Intestinal permeability was evaluated using lactulose (L) and mannitol (M) excretion. The association of MYO9B gene polymorphisms with intestinal permeability between the normal and high intestinal permeability groups was analyzed.

Results

Overall, there was no significant difference in the genotypic and allelic frequencies of MY

SUBMITTER: Hu J 

PROVIDER: S-EPMC4064092 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature