Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species.

ABSTRACT:

Background

Butein has various functions in human diseases including cancer. While anti-cancer effects of butein have been revealed, it is urgent to understand a unique role of butein against cancer. In this study, we demonstrate that butein inhibition of reactive oxygen species (ROS) production results in suppression of breast cancer growth.

Methods

Different breast cancer cell lines were treated with butein and then subjected to cell viability and apoptosis assays. Butein-sensitive or -resistant breast cancer cells were injected into mammary fat pads of immunocompromised mice and then butein was injected. Breast cancer cells were categorized on the basis of butein sensitivity.

Results

Butein reduced viabilities of different breast cancer cells, while not affecting th

SUBMITTER: Cho SG 

PROVIDER: S-EPMC4064524 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature