Interferon-induced genes of the expanded IFIT family show conserved antiviral activities in non-mammalian species.

ABSTRACT: Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in the protective response to viral infection, although the precise mechanism of IFITs for reducing viral proliferation is currently unknown. The interaction with the translation initiation factor eIF-3 or viral proteins and the sequestering of viral RNA have been proposed as potential antiviral functions for these proteins. In humans, four members of this family have been characterized. Nevertheless, information about these proteins in fish is almost non-existent. Exploiting the conservation of synteny between human and zebrafish genomes, we have identified ten members of the IFIT family located on four different chromosomes. The induction of these genes was examined both in vitro and in vivo after interferon

SUBMITTER: Varela M 

PROVIDER: S-EPMC4065003 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature