A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust.

ABSTRACT:

Background

Most asthma begins in the first years of life. This early onset cannot be attributed merely to genetic factors because the prevalence of asthma is increasing. Epidemiologic studies have indicated roles for prenatal and early childhood exposures, including exposure to diesel exhaust. However, little is known about the mechanisms. This is largely due to a paucity of animal models.

Objective

We aimed to develop a mouse model of asthma susceptibility through prenatal exposure to diesel exhaust.

Methods

Pregnant C57BL/6 female mice were given repeated intranasal applications of diesel exhaust particles (DEPs) or PBS. Offspring underwent suboptimal immunization and challenge with ovalbumin (OVA) or received PBS. Pups were examined for features of asthma; lung and

SUBMITTER: Manners S 

PROVIDER: S-EPMC4065237 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature